They cut until it affects safety, but yeah it’s juggling all the items to make it work for usa market. I guess we will never known if small gas tank is a result of just targeting specific milage or toyota was forced to make it smaller because of safety or other factors.Then there should be more aluminum body panels (besides the hood) like the LC300/Lexus LX have. This would save a lot more than 50 pounds.
Also, without the engineering data or analysis on how the tanks are crash tested, we probably don't know what other safety issues there are for alternative fuel tank designs. This is probably why there aren't plenty of US market aftermarket fuel tanks to choose from almost a year after the LC250 was introduced if there is an easy/obvious solution that Toyota's team of engineers missed. I'm no engineer, but I'm guessing since the main high voltage battery and 12v battery are both in the rear of the vehicle, the fuel tank needs to be well protected.